UK manufacturing output unexpectedly fell 0.7% in October, down from revised growth of 0.7% in September, according to official figures.
Economists had forecast a 0.2% increase in industrial and manufacturing output in October.
The Office for National Statistics (ONS) said output was hit by a sharp fall in computer and electronics manufacturing.
Compared with a year earlier, output from manufacturing was up 1.7%.
The monthly decline, which was the biggest since May, was hit by a 4.5% fall in computer, electronic and optical products.