The UK is “an economy of opportunity” which supports one million Scottish jobs, David Cameron is to tell business leaders.
The prime minister will address the CBI conference later, calling the UK one of the “most successful single markets”.
The speech takes place in the final weeks of the referendum campaign.
Scottish First Minister Alex Salmond challenged Mr Cameron to name a single job-creating power certain to come after a “No” vote.
In his address to the employers’ organisation, Mr Cameron is expected to say: “This is one of the oldest and most successful single markets in the world.
“Scotland does twice as much trade with the rest of the UK than with the rest of the world put together – trade that helps to support one million Scottish jobs.”
He will add: “This success doesn’t happen by accident. It happens because of the skill of people in Scotland and the opportunities that come from being part of something bigger.
“A large domestic market, underpinned by a common currency, common taxes, common rules and regulations, with no borders, no transaction costs, no restrictions on the flow of goods, investment or people. Ours really is an economy of opportunity.”