An ambitious 12-nation free trade plan, the Trans-Pacific Partnership (TPP), has hit a new roadblock after four days of negotiations in Singapore.
Sticking points over market access and differences over tariffs on imported goods were the main reasons cited.
TPP members were also aiming to set a common trading standard on a range of issues, including labour regulation and environmental protection.
Negotiators were initially hopeful that a draft deal would be ready in April.
That is when US President Barack Obama is scheduled to visit the region.
A TPP deal at that time would solidify the US pivot to Asia.
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